Analytical Data
-
基因名
SOCS1
-
简介
The SOCS1 protein is an important negative regulator that inhibits type I and type II interferon signaling as well as cytokines such as IL2, IL4, IL6, and LIF. It downregulates the signaling of the JAK/STAT pathway by inhibiting JAK proteins and IFNGR1. SOCS1 Protein, Human (P.pastoris, His) is the recombinant human-derived SOCS1 protein, expressed by P. pastoris , with N-His labeled tag.
- Application
-
别名
CISH 1; CISH1; Cytokine inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; Janus kinase binding protein ; SOCS 1; TEC interacting protein 3; Tec-interacting protein 3; TIP 3
-
种属
Human
-
表达系统
P. pastoris
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O15524
-
表达区间
M1-I211
-
氨基酸序列
MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI
-
蛋白长度
Full Length
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SOCS1 (Suppressor of Cytokine Signaling 1) is a critical regulator of cytokine signaling pathways, primarily involved in modulating immune responses and inflammation. It is a member of the SOCS family, which plays a crucial role in the negative feedback regulation of various cytokines, especially those of the IL-6 family and the JAK-STAT signaling pathway. Dysregulation of SOCS1 has been implicated in a variety of pathological conditions, including autoimmune diseases, chronic inflammation, and cancer. Recent studies have highlighted the role of SOCS1 as a tumor suppressor, suggesting that its loss or mutation may contribute to tumorigenesis. Additionally, SOCS1 has been shown to influence various cellular processes, such as cell proliferation, apoptosis, and differentiation. Given its important functions, researchers are increasingly focused on understanding the molecular mechanisms underlying SOCS1's action and exploring its potential as a therapeutic target. This includes the study of SOCS1 recombinant proteins to elucidate their structural and functional properties, which could pave the way for developing novel interventions in diseases characterized by aberrant cytokine signaling. Understanding SOCS1's role at the molecular level may also provide insights into more effective treatment strategies for immune-related disorders and cancers, highlighting its significance in both basic research and clinical applications.
