Analytical Data
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Gene name
Immunoglobulin J chain
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简介
The Immunoglobulin J chain links IgM or IgA monomers. In IgM, J chain-joined dimers nucleate the IgM pentamer, while in IgA, it induces dimer or polymer formation. It also binds these immunoglobulins to the secretory component. As part of the sIgA complex, it integrates with IgA monomers, the J chain, and the secretory component (PIGR proteolytic product). Immunoglobulin J chain Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Immunoglobulin J chain protein, expressed by P. pastoris , with N-His labeled tag.
- Application
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Alternative Names
Jchain; IgjImmunoglobulin J chain
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Species
Mouse
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Source
P. pastoris
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P01592
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Expression Region
G22-D159
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Protein Length
Full Length of Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Immunoglobulin J chain (IgJ) is a crucial component of the immune system, playing a vital role in the polymerization of immunoglobulin molecules, such as IgA and IgM, which are essential for effective immune responses. The J chain facilitates the formation of pentameric IgM and dimeric IgA, ensuring optimal antibody function and transport across mucosal surfaces. Given its significance in immune regulation and potential implications in vaccine development and therapeutics, research has focused on characterizing the IgJ gene and its protein products. Recombinant IgJ proteins offer a valuable tool for understanding its biological functions, interactions with different immunoglobulins, and roles in immune system disorders. Advanced techniques in molecular biology, such as cloning and expression systems, have been employed to produce functional IgJ proteins, enabling detailed studies of their structural and functional properties. Furthermore, recombinant J chain proteins hold promise for developing novel immune-modulating therapies and enhancing vaccine efficacy by improving antibody responses. Research in this area is pivotal for uncovering new strategies to harness the immune system against infections and diseases, making IgJ a significant target in immunological studies.
