Analytical Data
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Gene name
SNTG1
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简介
SNTG1 acts as an adapter protein that binds and potentially organizes various proteins, serving as a link between the receptor and the actin cytoskeleton or dystrophin glycoprotein complex. It may modulate the subcellular distribution of diacylglycerol kinase-zeta and contribute to the rapid inactivation of diacylglycerol upon receptor activation. SNTG1 Protein, Human (Myc, His) is the recombinant human-derived SNTG1 protein, expressed by E. coli , with N-His, C-Myc labeled tag.
- Application
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Alternative Names
G1SYN; Gamma 1 syntrophin; SNTG 1; Sntg1; SNTG1_HUMAN; SYN 4; SYN4; Synotrophin gamma 1; Syntrophin 4; Syntrophin gamma 1; Syntrophin-4
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Species
Human
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Source
E. coli
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Tag
N-His;C-Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NSN8-1
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Expression Region
M1-T517
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AA Sequence
MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTVQSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT
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Protein Length
Full Length of Isoform-1
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNTG1 (Syntrophin Gamma 1) is a member of the syntrophin family, which plays a crucial role in linking signaling proteins to the dystrophin-associated protein complex in muscle tissues. Initially identified for its involvement in muscular dystrophies, SNTG1 has gained attention in recent years due to its potential implications in various biological processes, including cell signaling, cytoskeletal organization, and membrane dynamics. Research has indicated that SNTG1 may have a role in modulating intracellular signaling pathways, particularly in response to mechanical stress and cellular stimuli, which can affect muscle integrity and functionality. Additionally, SNTG1 has been implicated in the pathophysiology of several diseases, such as heart failure and neurodegenerative disorders, highlighting its importance beyond muscle tissue. The recombinant production of SNTG1 protein has enabled scientists to investigate its structure-function relationships, elucidating its interaction with other proteins and its role in cellular processes. Understanding SNTG1's molecular mechanisms is essential for exploring potential therapeutic targets and strategies for diseases associated with its dysfunction. This burgeoning field of research aims to establish SNTG1 not only as a fundamental component of muscle biology but also as a significant player in broader physiological and pathological contexts.
