Analytical Data
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基因名
SOST
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简介
SOST protein inhibits bone growth by suppressing Wnt signaling and interacting with LRP4 and LRP5. Its interactions with LRP4 and LRP5 play crucial roles in suppressing Wnt signaling. The involvement of SOST in interactions with LRP6 highlights its regulatory role in bone growth. SOST Protein, Rat (Myc, His) is the recombinant rat-derived SOST protein, expressed by E. coli , with N-His, C-Myc labeled tag.
- Application
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别名
Sost; Sclerostin
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种属
Rat
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表达系统
E. coli
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标签
N-His;C-Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99P67
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表达区间
F29-Y213
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氨基酸序列
FKNDATEIIPGLREYPEPPQELENNQTMNRAENGGRPPHHPYDTKDVSEYSCRELHYTRFVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRVKWWRPNGPDFRCIPDRYRAQRVQLLCPGGAAPRSRKVRLVASCKCKRLTRFHNQSELKDFGPETARPQKGRKPRPRARGAKANQAELENAY
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蛋白长度
Full Length of Mature Protein
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Collectrin, also known as TMEM27, is a transmembrane protein that plays a crucial role in various physiological processes, particularly in kidney function and glucose homeostasis. Initially discovered for its involvement in the secretion of insulin by pancreatic beta cells, Collectrin has garnered attention due to its implications in metabolic disorders such as obesity and diabetes. Research shows that Collectrin facilitates the proper positioning of glucose transporters and is implicated in the regulation of renal ion balance, making it vital for maintaining homeostasis. Recent studies have explored its potential role as a biomarker for kidney injury and as a therapeutic target for metabolic diseases. The recombinant form of Collectrin/TMEM27 allows for in-depth characterization of its structural and functional properties, enabling scientists to dissect its mechanisms of action and interactions with other proteins within cellular pathways. Thus, understanding the biology of Collectrin not only enhances our knowledge of metabolic regulation but also offers promising avenues for developing interventions for related disorders.
