Analytical Data
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基因名
KRT35
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简介
KRT35 Protein shows early expression in the hair follicle, primarily localized in supramatricial and lowermost cortical cells of the hair bulb. KRT35 Protein, Human (His) is the recombinant human-derived KRT35 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
Hair keratin; Hair keratin; type I Ha5; HHA5; HKA5; K35; Keratin; Keratin; type I cuticular Ha5; Keratin-35; KRT35; KRTHA5; type I cuticular Ha5; type I Ha5
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92764
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表达区间
M1-F455
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氨基酸序列
MASKCLKAGFSSGSLKSPGGASGGSTRVSAMYSSSSCKLPSLSPVARSFSACSVGLGRSSYRATSCLPALCLPAGGFATSYSGGGGWFGEGILTGNEKETMQSLNDRLAGYLEKVRQLEQENASLESRIREWCEQQVPYMCPDYQSYFRTIEELQKKTLCSKAENARLVVEIDNAKLAADDFRTKYETEVSLRQLVESDINGLRRILDDLTLCKSDLEAQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRVLEEMRCQYETLVENNRRDAEDWLDTQSEELNQQVVSSSEQLQSCQAEIIELRRTVNALEIELQAQHSMRDALESTLAETEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEYQVLLDVRARLECEINTYRGLLESEDSKLPCNPCAPDYSPSKSCLPCLPAASCGPSAARTNCSPRPICVPCPGGRF
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蛋白长度
Full Length
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分子量
52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT35, or Keratin 35, is a member of the keratin family, primarily associated with the intermediate filaments of epithelial cells. The study of KRT35 has gained importance due to its potential roles in skin biology, epithelial integrity, and various pathological conditions, including cancer and skin disorders. Keratins are critical components of the cytoskeleton, providing structural support and playing a role in cellular processes such as proliferation, differentiation, and apoptosis. KRT35, specifically, is expressed in certain epithelial tissues, and its dysregulation has been implicated in various diseases. Recent research has focused on characterizing the functional properties of KRT35, including its role in cellular mechanisms and interactions with other proteins. Understanding the reconstitution and functional significance of KRT35 can provide insights into its contribution to maintaining tissue homeostasis and its involvement in disease states. By studying KRT35's structure and interactions, researchers aim to elucidate its biological functions, which could lead to novel therapeutic targets and biomarkers for epithelial-related diseases. Thus, ongoing investigations into KRT35 recombinant proteins serve not only to advance fundamental knowledge in cellular biology but also to pave the way for clinical applications in diagnosing and treating conditions linked to keratin dysfunction.
