Analytical Data
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基因名
PLA2G2D
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简介
PLA2G2D protein is a secreted calcium-dependent phospholipase A2 that targets extracellular lipids and has anti-inflammatory and immunosuppressive functions.It hydrolyzes the fatty acyl group at the sn-2 position, preferentially hydrolyzing phosphatidylethanolamine and phosphatidylglycerol.PLA2G2D Protein, Human (His-SUMO) is the recombinant human-derived PLA2G2D protein, expressed by E.coli , with N-His, N-SUMO labeled tag.
- Application
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别名
2IID; EC 3.1.1.4; GIID sPLA2; Group IID secretory phospholipase A2; Phospholipase A2 group IID ; Pla2g2d; PLA2IID; stroma-associated homolog
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种属
Human
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表达系统
E. coli
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标签
N-SUMO;N-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q9UNK4
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表达区间
I22-C145
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蛋白长度
Partial
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分子量
30 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLA2G2D, a member of the phospholipase A2 (PLA2) family, has garnered significant attention due to its potential roles in various physiological and pathological processes. Structurally, PLA2G2D is an enzyme that catalyzes the hydrolysis of phospholipids, leading to the generation of lysolipids and free fatty acids, which are crucial for cell signaling, membrane dynamics, and inflammation. Research has indicated that PLA2G2D might play a role in immune responses, particularly in modulating the activity of immune cells and influencing the progression of inflammatory diseases. Its expression has been linked to cancer and other diseases, making it a potential therapeutic target. The generation of recombinant PLA2G2D proteins has facilitated the exploration of their structure-function relationships, as well as their interactions with various biological substrates. These studies are vital for understanding the enzyme's biological significance and its potential as a diagnostic or therapeutic biomarker in diseases. Moreover, characterizing PLA2G2D can also provide insights into the broader functions of phospholipases and their involvement in lipid metabolism. Overall, the investigation of PLA2G2D recombinant proteins is a promising avenue for advancing our understanding of lipid mediators in health and disease.
