Analytical Data
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基因名
TSST-1
- Application
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别名
tst; Toxic shock syndrome toxin-1; TSST-1
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种属
Staphylococcus aureus
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表达系统
E. coli
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标签
N-His;N-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06886
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表达区间
S41-N234
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氨基酸序列
STNDNIKDLLDWYSSGSDTFTNSEVLDNSLGSMRIKNTDGSISLIIFPSPYYSPAFTKGEKVDLNTKRTKKSQHTSEGTYIHFQISGVTNTEKLPTPIELPLKVKVHGKDSPLKYGPKFDKKQLAISTLDFEIRHQLTQIHGLYRSSDKTGGYWKITMNDGSTYQSDLSKKFEYNTEKPPINIDEIKTIEAEIN
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蛋白长度
Full Length of Mature Protein
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TSST-1 (Toxic Shock Syndrome Toxin-1) is a potent superantigen produced by Staphylococcus aureus, associated with toxic shock syndrome (TSS), a severe illness characterized by high fever, rash, and multi-organ failure. The interaction between TSST-1 and the immune system leads to the activation of a large number of T cells, resulting in a cytokine storm that can be life-threatening. Research on recombinant TSST-1 utilizes genetic engineering techniques to produce the protein in vitro, enabling detailed study of its structure and function without the risks associated with pathogenic strains. This approach provides insights into the mechanisms of TSS and the potential for developing vaccines or therapeutics targeting TSST-1 or its effects. Additionally, recombinant TSST-1 can serve as a tool for studying superantigenic stimulation and its role in various autoimmune diseases. Understanding the biology of TSST-1 can also contribute to the development of strategies to modulate immune responses, with implications for both infectious diseases and immunological disorders. Overall, the study of recombinant TSST-1 is vital for advancing our knowledge of superantigens and their impact on human health.
