Analytical Data
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Gene name
OGN/Osteoglycin
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简介
OGN/Osteoglycin protein collaborates with TGF-beta-1 or TGF-beta-2 to regulate bone formation. It interacts synergistically with specific isoforms of TGF-beta, modulating bone development and remodeling. This highlights OGN's significance in bone homeostasis and its potential as a therapeutic target for bone-related conditions. OGN/Osteoglycin Protein, Mouse (HEK293, His) is the recombinant mouse-derived OGN/Osteoglycin protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Biological Activity
Measured by its ability to modulate collagen fibrillogenesis. At 15 µg/mL, OGN can significantly retard the rate of type I collagen fibrillogenesis. Measured by its ability to modulate collagen fibrillogenesis. At 15 µg/mL, OGN can significantly retard the rate of type I collagen fibrillogenesis.
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Alternative Names
Mimecan; DKFZp586P2421; KSPG25; mimecan proteoglycan; Mimecan; OGN; OIF; OIFOG; osteoglycin; Osteoinductive factor; SLRR3A; SLRR3Acorneal keratan sulfate proteoglycan
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Species
Mouse
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q62000
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Expression Region
A20-F298
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AA Sequence
APQSQLDSHVNYEYATGNSEETKFSQDYEDKYLDGKSIKEKETMIIPDEKSLQLQKDEVIPSLPTKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADMPNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQLLRLPVLPPKLTLLNAKHNKIKSKGIKANTFKKLNKLSFLYLDHNDLESVPPNLPESLRVIHLQFNSISSLTDDTFCKANDTRYIRERIEEIRLEGNPIALGKHPNSFICLKRLPIGSYF
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Protein Length
Full Length of Mature Protein
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Molecular Weight
44-45 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Osteoglycin (OGN) is a small leucine-rich proteoglycan that plays a crucial role in bone and cartilage development, tissue repair, and cell signaling. Emerging research highlights its significance in the extracellular matrix, influencing cellular activities like proliferation and differentiation. Alterations in OGN expression have been linked to various musculoskeletal disorders, including osteoarthritis and osteoporosis, making it a potential biomarker and therapeutic target. The study of recombinant OGN protein offers insights into its precise biological functions and mechanisms. Through recombinant technology, scientists can produce and manipulate OGN for in-depth functional analyses, paving the way for novel treatments aimed at restoring tissue integrity and function in degenerative diseases. Ongoing investigations focus on understanding OGN's interactions within the extracellular matrix and its effects on cartilage homeostasis, which may lead to innovative therapeutic strategies. Overall, research on recombinant OGN protein not only enhances our understanding of its fundamental biological roles but also contributes to advancing regenerative medicine approaches for treating musculoskeletal disorders.
