Analytical Data
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基因名
LOX-1/OLR1
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简介
The LOX-1/OLR1 protein plays an important role as a receptor that recognizes, internalizes, and degrades oxidatively modified low-density lipoprotein (oxLDL), a marker of atherosclerosis, in vascular endothelial cells. OxLDL induces endothelial dysfunction, triggering pro-inflammatory responses, oxidative conditions, and apoptosis. LOX-1/OLR1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived LOX-1/OLR1 protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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别名
Oxidized low-density lipoprotein receptor 1; LOX-1; OLR1; CLEC8A
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种属
Rat
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表达系统
HEK293
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标签
N-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O70156
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表达区间
L60-Q364
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蛋白长度
Partial
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分子量
66 kDa & 35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) is a type of scavenger receptor that plays a crucial role in cellular uptake of oxidized low-density lipoproteins (oxLDL), thus contributing to atherogenesis and cardiovascular diseases. It is primarily expressed in endothelial cells, macrophages, and vascular smooth muscle cells, where it is implicated in inflammatory processes and endothelial dysfunction. The binding of oxLDL to LOX-1 triggers several intracellular signaling pathways that promote inflammation, oxidative stress, and apoptosis, which are fundamental in the development of atherosclerosis.
OLR1, the gene encoding LOX-1, has emerged as a significant target for investigating potential therapeutic interventions in vascular diseases. Recombinant LOX-1 protein studies allow for the elucidation of its structure-function relationship, the elucidation of its ligand-binding properties, and the investigation of its signaling mechanisms. Furthermore, understanding LOX-1's interactions with various ligands can provide insights into the pathophysiological roles of this receptor in cardiovascular diseases. As such, research into LOX-1 and its recombinant forms is vital for developing strategies aimed at modulating its activity for therapeutic benefits, particularly in managing conditions associated with dyslipidemia and atherosclerosis. Additionally, recombinant LOX-1 proteins can serve as valuable tools in drug discovery and the development of diagnostic markers, underscoring their importance in cardiovascular research. Overall, the investigation of LOX-1/OLR1 recombinant proteins represents a critical avenue for enhancing our understanding of cardiovascular pathology and potential treatment modalities.
