Analytical Data
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基因名
Neurocalcin-delta/NCALD
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简介
Neurocalcin-delta/NCALD proteins are involved in calcium-dependent regulation of rhodopsin phosphorylation, affecting dynamics critical for visual signal transduction. NCALD is capable of binding three calcium ions and is important in calcium-mediated pathways that control photoreceptor function. Neurocalcin-delta/NCALD Protein, Human (His) is the recombinant human-derived Neurocalcin-delta/NCALD protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
rHuNeurocalcin-delta/NCALD, His; Neurocalcin-Delta; NCALD
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P61601
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表达区间
M1-F193
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氨基酸序列
MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNRDGKLSLEEFIRGAKSDPSIVRLLQCDPSSAGQF
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蛋白长度
Full Length
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分子量
20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Neurocalcin-delta (NCALD) is a member of the neurocalcin family, proteins characterized by their calcium-binding abilities and potential roles in neuronal signaling and synaptic functions. Initially studied for its involvement in neuronal development and differentiation, NCALD has garnered interest for its potential implications in neurodegenerative diseases and brain disorders. Research indicates that NCALD is highly expressed in the brain and plays a crucial role in calcium homeostasis, which is vital for various neuronal functions, including neurotransmitter release and synaptic plasticity. The recombinant expression of NCALD has enabled scientists to investigate its structural and functional properties in vitro, leading to a deeper understanding of its mechanisms of action. With the rising prevalence of neurological disorders linked to calcium dysregulation, such as Alzheimer's disease and Parkinson's disease, exploring the functional dynamics of NCALD can aid in the development of therapeutic approaches. Moreover, studying NCALD in different model systems may uncover its potential as a biomarker for early diagnosis or progression of neurological conditions. The recombination technology has provided a powerful platform for producing NCALD, facilitating studies on its interactions, physiological roles, and therapeutic possibilities, thus opening new avenues for neurobiology research.
