Analytical Data
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基因名
Tau-F/2N4R
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简介
Microtubule-associated protein tau is a microtubule-associated protein found in large numbers in neurons of the central nervous system (CNS). MAPT promotes microtubule assembly and stability and may be involved in the establishment and maintenance of neuronal polarity. Overexpression of MAPT is associated with a poor prognosis of prostate cancer. MAPT has been linked to neurological disorders such as Alzheimer's and Parkinson's disease. Tau-F/2N4R Protein, Human (HEK293, His) is the recombinant human-derived Tau-F/2N4R protein, expressed by HEK293 , with N-10*His labeled tag.
- Application
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种属
Human
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表达系统
HEK293
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标签
N-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10636-8
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表达区间
M1-L441
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氨基酸序列
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
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蛋白长度
Full Length of Isoform Tau-F
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分子量
110 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The Tau-F/2N4R recombinant protein is a crucial element in the study of tauopathies, neurodegenerative disorders characterized by the aggregation of tau protein in the brain. Tau protein plays an essential role in stabilizing microtubules, and its dysfunction leads to tau hyperphosphorylation and the formation of neurofibrillary tangles, a hallmark of diseases such as Alzheimer's. The Tau-F isoform, a specific variant of tau, is particularly relevant due to its four repeat domains (2N4R), making it a prime candidate for investigating tau's pathological roles. Research on Tau-F/2N4R aims to elucidate the mechanisms behind tau aggregation and propagation, providing insights into disease progression and potential therapeutic targets. Recombinant expression systems allow for the production of this protein in controlled environments, facilitating studies on its biophysical properties, interaction with other cellular components, and the effects of various post-translational modifications. By understanding the structural and functional characteristics of Tau-F/2N4R, researchers hope to develop strategies for intervention and treatment of tau-related neurodegenerative conditions, thus addressing a critical unmet need in the field of neuroscience.
