Analytical Data
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基因名
Calnexin
- Application
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别名
rHuCalnexin, His; Calnexin; IP90; Major Histocompatibility Complex Class I Antigen-Binding Protein p88; CANX
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P27824
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表达区间
H21-P481
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氨基酸序列
HDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAEPGVVGQMIEAAEERPHHHHHH
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蛋白长度
Lumenal Domain
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分子量
70.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Calnexin is a membrane-associated chaperone protein predominantly found in the endoplasmic reticulum (ER), playing a critical role in the proper folding and quality control of newly synthesized glycoproteins. Its unique structure, featuring a lectin domain that recognizes specific carbohydrate moieties on nascent glycoproteins, enables it to assist in their proper folding and prevent aggregation. Research has shown that Calnexin interacts with a variety of client proteins, influencing their stability, functionality, and transport to the Golgi apparatus. Given its essential role in the protein maturation process, Calnexin has garnered significant interest in studies related to various diseases, including neurodegenerative disorders, where protein misfolding is a key feature. Additionally, its involvement in the immune response and cellular stress response pathways underscores its importance in maintaining cellular homeostasis. Research on recombinant Calnexin has advanced our understanding of its mechanistic functions and potential therapeutic roles, paving the way for novel strategies to address diseases associated with protein misfolding and ER stress. By investigating the protein's structure-function relationships and interaction networks through recombinant expression systems, researchers aim to develop targeted therapeutics that can modulate Calnexin's activity, thereby enhancing protein folding processes in pathological conditions.
