Analytical Data
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基因名
CELA2A
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简介
The function of the CELA2A protein as elastase goes beyond its traditional role as it not only enhances insulin signaling but also appears to play a potential physiological role in cellular glucose metabolism. This multifaceted protein circulates in the plasma and exerts regulatory effects by reducing platelet overactivation. CELA2A Protein, Human (His) is the recombinant human-derived CELA2A protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
CELA2A; ELA2A; Chymotrypsin-like elastase family member 2A; EC 3.4.21.71; Elastase-2A
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08217
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表达区间
V29-N269
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氨基酸序列
VVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWINSVIANN
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蛋白长度
Full Length of Mature Protein
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分子量
29.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The CELA2A protein, classified as a serine protease, has gained significant attention in the fields of biochemistry and molecular biology due to its potential implications in physiological processes and disease states. CELA2A is primarily expressed in the pancreas and plays a pivotal role in the digestion of dietary proteins, making it a crucial component of the digestive enzyme repertoire. Research has revealed its significance in various pathological conditions, such as pancreatic disorders and inflammation. The study of CELA2A's structure, function, and regulatory mechanisms is essential for understanding its role in health and disease.
Recent advances in recombinant DNA technology have enabled the expression and purification of CELA2A for in-depth functional analyses and structural characterization. These studies aim to elucidate the substrate specificity of CELA2A, its interaction with other biomolecules, and its enzymatic activities. Furthermore, the exploration of CELA2A's role in cellular signaling pathways could lead to potential therapeutic applications, particularly in conditions associated with protease dysregulation. Overall, the ongoing research on CELA2A not only enhances our understanding of digestive physiology but also holds promise for developing novel strategies for treating related disorders.
