Analytical Data
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基因名
Apolipoprotein E/APOE3
- Application
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别名
Apo-E; AD2; Apoprotein; Alzheimer Disease 2(E4-Associated,Late Onset
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种属
Pig
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P18650
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表达区间
Cys16~Arg175
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分子量
25kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Apolipoprotein E (ApoE) is a key protein involved in lipid metabolism and is critically implicated in neurodegenerative diseases, particularly Alzheimer’s disease. Among its three major isoforms, ApoE2, ApoE3, and ApoE4, ApoE3 is the most common and is often considered the “neutral” variant, playing a protective role against Alzheimer’s compared to ApoE4, which is associated with increased risk for the disease. Research on recombinant ApoE3 protein has garnered significant interest due to its potential therapeutic implications. Understanding the structure and function of ApoE3 can provide insights into its role in neuroinflammation, cholesterol transport, and synaptic repair. Advances in recombinant DNA technology have enabled the production of ApoE3 in vitro, facilitating studies on its biochemical properties, interactions with lipoproteins, and impact on neuronal cells. Such research aims to elucidate the molecular mechanisms underlying ApoE3’s protective effects and could lead to novel strategies for intervention in Alzheimer’s disease and other neurodegenerative disorders. By exploring the functional dynamics of recombinant ApoE3, scientists hope to pave the way for targeted therapies that could mitigate the effects of ApoE4 and enhance brain health.
