Analytical Data
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基因名
Nectin-4
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简介
The Nectin-4 Protein IgV domain is pivotal in cell adhesion, participating in trans-homophilic and -heterophilic interactions, notably with NECTIN1. While it doesn't serve as an alpha-herpesvirus entry receptor, it functions as a receptor for measles virus, enabling virus entry into host cells. This dual role underscores the importance of Nectin-4 in cell adhesion and its specific role as a measles virus infection receptor. Nectin-4 Protein, Human (HEK293, Fc) is the recombinant human-derived Nectin-4 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
EDSS1; LNIR; Nectin4; PRR4; NECTIN4; PVRL4
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96NY8-1
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表达区间
G32-S349
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蛋白长度
Extracellular Domain
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分子量
72-74 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Nectin-4 is a member of the immunoglobulin superfamily and plays a crucial role in cellular adhesion and signaling. It is predominantly expressed in epithelial tissues and is known for its involvement in various physiological processes, including cellular differentiation, proliferation, and immune response regulation. Recent studies have highlighted Nectin-4 as an emerging target in cancer research, particularly in breast and ovarian cancers, where it is often overexpressed. This overexpression correlates with poor prognosis and increased tumor aggressiveness, making Nectin-4 a potential biomarker for cancer progression. The generation of recombinant Nectin-4 proteins has facilitated the exploration of its functional properties and interactions with other cellular components. Such research aims to understand the molecular mechanisms by which Nectin-4 contributes to tumorigenesis and cancer metastasis. Furthermore, recombinant Nectin-4 is being investigated as a target for novel therapeutic strategies, including antibody-based treatments that can elicit immune responses against Nectin-4-expressing tumor cells. Overall, the study of recombinant Nectin-4 proteins is paving the way for innovative cancer therapies and improved diagnostic tools, ultimately contributing to better management of Nectin-4-associated malignancies.
