Analytical Data
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Gene name
TROP-2
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简介
The TROP-2 protein emerged as a potential growth factor receptor, implying involvement in cellular processes related to growth and signaling. As a putative receptor, TROP-2 may play a crucial role in transducing signals that regulate cell growth and proliferation. TROP-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TROP-2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Biological Activity
1.Immobilized Cynomolgus TROP-2 at 0.5 μg/ml (100μL/Well). Dose response curve for Anti-TROP-2 Antibody, hFc Tag with the EC50 of 2.8 ng/ml determined by ELISA. 2.Measured by its binding ability in a functional ELISA. Immobilized Human IGF2R at 1 μg/mL (100μL/well) can bind biotinylated Cynomolgus TROP-2, The ED50 for this effect is 0.1566 μg/mL. Measured by its binding ability in a functional ELISA. Immobilized Human IGF2R at 1 μg/mL (100 μL/well) can bind biotinylated Cynomolgus TROP-2, The ED50 for this effect is 0.1566 μg/mL.
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Alternative Names
EGP1; EGP-1; TROP2; GA733-1; gp50; T16; TACSTD2; TROP-2; M1S1; TACD2
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Species
Cynomolgus
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
XP_005543292
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Expression Region
H27-T274
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AA Sequence
HTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGSGVAVDCSTLTSKCLLLKARMSAPKNARTLVRPNEHALVDNDGLYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDVKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLT
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Protein Length
Partial
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Molecular Weight
37-55 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TROP-2, a transmembrane glycoprotein, has emerged as a significant target in cancer research due to its overexpression in various malignancies, including breast, lung, and colon cancers. Initially identified as an early developmental marker, TROP-2 plays a critical role in cellular adhesion and signaling pathways that promote tumor growth and metastasis. Its involvement in cancer progression has led to increased interest in developing TROP-2-targeted therapies, such as antibody-drug conjugates (ADCs) that deliver cytotoxic agents specifically to tumor cells expressing this protein. The unique expression pattern of TROP-2 in tumors, coupled with its limited presence in normal tissues, underscores its potential as a therapeutic target. Recent studies have focused on elucidating the molecular mechanisms by which TROP-2 contributes to oncogenesis and exploring its potential in combination therapies to enhance treatment efficacy. As a result, the development of TROP-2-targeted therapies is poised to improve outcomes for patients with TROP-2-positive cancers, making it a critical area of investigation in the quest for more effective cancer treatments.
