Analytical Data
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Gene name
CD8 beta
- Application
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Alternative Names
CD8B1; CD8 Antigen,Beta Polypeptide 1; T-cell surface glycoprotein CD8 beta chain
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10300
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Expression Region
Leu22~Thr175
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Molecular Weight
21kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD8 beta is a glycoprotein that plays a crucial role in the immune response, particularly in the activation and function of cytotoxic T cells, which are essential for eliminating infected or malignant cells. The CD8 molecule consists of two subunits: CD8 alpha and CD8 beta, with the beta chain contributing to the overall stability and function of the CD8 complex. Research into CD8 beta recombinants has gained momentum due to their potential applications in immunotherapy, vaccine development, and understanding T cell signaling pathways. The ability to produce CD8 beta as a recombinant protein allows for detailed studies on its structure, interactions with major histocompatibility complex (MHC) molecules, and its role in T cell development and activation. Furthermore, understanding the distinct functions of the CD8 alpha and beta chains can help in designing more targeted immunotherapeutic strategies for diseases like cancer and viral infections. By elucidating the molecular mechanisms underlying CD8 beta's contribution to T cell responses, researchers aim to enhance the efficacy of immune-based therapies and improve patient outcomes. Overall, the investigation of CD8 beta recombination and function is pivotal in advancing our knowledge of T cell biology and developing innovative approaches for boosting the immune response in clinical settings.
