Analytical Data
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基因名
IL-20
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简介
IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. IL-20 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-20 protein, expressed by HEK293 , with N-His labeled tag.
- Application
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生物活性
Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human IL-20 R alpha and human IL-20 R beta. The ED50 for this effect is 1.358 ng/mL. Corresponding to a specific activity is 7.364×105 units/mg. Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human IL-20 R alpha and human IL-20 R beta. The ED50 for this effect is 1.358 ng/mL. corresponding to a specific activity is 7.364×105 units/mg.
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别名
IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907
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种属
Mouse
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表达系统
HEK293
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标签
N-His
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纯度
Greater than 95% as determined by reducing SDS-PAGE. as determined by SDS-PAGE.
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蛋白编号
Q9JKV9
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表达区间
Leu25~Leu176
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蛋白长度
Full Length of Mature Protein
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分子量
20-22 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-20 (IL-20) is a cytokine belonging to the IL-10 family, primarily expressed in the skin and associated with various inflammatory and autoimmune diseases, such as psoriasis and atopic dermatitis. Its role in promoting keratinocyte proliferation and differentiation has attracted considerable attention, highlighting its potential as a therapeutic target. Recent studies have shown that IL-20 can modulate immune responses and influence the inflammatory microenvironment, making it crucial in the pathogenesis of skin disorders. The generation of recombinant IL-20 proteins has enabled researchers to investigate the precise mechanisms of this cytokine and its receptor interactions. Such studies are pivotal for understanding the signaling pathways involved in skin inflammation and repairing damaged tissues. Furthermore, exploring IL-20's potential in clinical applications, such as targeted therapies for chronic skin diseases, underscores the importance of recombinant IL-20 in therapeutic research. The intricate balance between IL-20 and other cytokines suggests that manipulating its levels could lead to innovative treatment options, addressing the unmet medical needs of patients suffering from debilitating skin conditions. As research progresses, the therapeutic potential of IL-20 continues to be explored, reinforcing its significance in dermatological studies and treatment strategies.
