Analytical Data
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基因名
CD8 alpha
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简介
CD8A is an important immune glycoprotein that acts as a coreceptor for class I MHC:peptide complexes, linking T cells to antigens presented by APCs. It interacts with TCR and MHC class I, recruits LCK kinase, and initiates multiple signaling pathways. CD8 alpha Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD8 alpha protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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生物活性
Measured by its ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. The ED50 for this effect is 2.938 μg/mL, corresponding to a specific activity is 340.368 units/mg. Measured by its ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. The ED50 for this effect is 2.938 μg/mL, corresponding to a specific activity is 340.368 units/mg.
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别名
T-cell surface glycoprotein CD8 alpha chain; CD8a; CD8A; MAL
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01731-1
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表达区间
K28-Y196
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氨基酸序列
MASPLTRFLSLNLLLLGESIILGSGEAKPQAPELRIFPKKMDAELGQKVDLVCEVLGSVSQGCSWLFQNSSSKLPQPTFVVYMASSHNKITWDEKLNSSKLFSAMRDTNNKYVLTLNKFSKENEGYYFCSVISNSVMYFSSVVPVLQKVNSTTTKPVLRTPSPVHPTGTSQPQRPEDCRPRGSVKGTGLDFACDIY
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蛋白长度
Extracellular Domain
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分子量
45.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD8 alpha (CD8α) is an essential co-receptor expressed on cytotoxic T lymphocytes, playing a crucial role in the immune response by enhancing the recognition of antigen-presenting cells and facilitating the activation of T cells. The importance of CD8α in immune surveillance and tumor rejection has prompted extensive research into its structure and function. Understanding CD8α at the molecular level can lead to insights for improving immunotherapeutic strategies, particularly in cancer treatment and viral infections. Recombinant CD8α protein, produced using advanced biotechnology techniques, offers a valuable tool for studying its interactions with MHC I molecules and T cell receptors. Furthermore, this recombinant protein can be utilized in various applications, including vaccine development and as a potential target for monoclonal antibody therapy. Given the growing interest in harnessing the immune system to combat diseases, research on CD8α recombinant protein remains critical for advancing our knowledge of T cell biology and improving therapeutic outcomes in immunotherapy.
