Analytical Data
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Gene name
IL-16
- Application
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Alternative Names
Pro-interleukin-16; Interleukin-16; IL-16; Lymphocyte chemoattractant factor; LCF
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Species
Human
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Source
E. coli
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Tag
C-6*His
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Purity
> 90% as determined by SDS-PAGE.
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Uniprot
Q14005
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Expression Region
M593-S721
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Protein Length
Partial
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Molecular Weight
18 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-16, a cytokine initially identified as a chemoattractant for CD4+ T cells, plays a significant role in immune regulation and inflammation. It is primarily produced by various immune cells, including CD8+ T cells, dendritic cells, and certain epithelial cells, and it functions through its receptor, CD4, initiating several signaling pathways that affect T cell proliferation and activity. Research on IL-16 has intensified due to its involvement in various inflammatory diseases, including asthma, rheumatoid arthritis, and multiple sclerosis, where it can exacerbate immune responses. The role of IL-16 as an immunomodulator suggests potential therapeutic applications in managing autoimmune diseases and conditions characterized by chronic inflammation. The development of recombinant IL-16 protein has enabled researchers to study its biological functions in vitro and in vivo, providing insights into its mechanisms of action and potential for therapeutic targeting. By examining the effects of IL-16 on immune cell behavior and its interaction with other cytokines, scientists aim to uncover the pathways through which IL-16 influences immune responses, thereby contributing to the development of novel treatment strategies. Understanding IL-16's multifaceted role in the immune system is crucial for elucidating its potential as a biomarker for disease progression and a target for therapeutic intervention, paving the way for advancements in precision medicine for inflammatory disorders.
