Analytical Data
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基因名
IL-11
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简介
IL-11 protein is a potent cytokine that significantly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, leading to megakaryocyte maturation and platelet production. It also promotes hepatocyte proliferation in response to liver injury. IL-11 Protein, Cynomolgus is the recombinant cynomolgus-derived IL-11 protein, expressed by E. coli , with tag free.
- Application
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生物活性
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 4.216 ng/mL, corresponding to a specific activity is 2.371×105 units/mg. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 4.216 ng/mL，corresponding to a specific activity is 2.371×105 units/mg.
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别名
Interleukin-11; Il11; Adipogenesis Inhibitory Factor; AGIF
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种属
Cynomolgus
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by reducing SDS-PAGE. as determined by SDS-PAGE.
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蛋白编号
XP_005595839.2
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表达区间
P22-L199
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蛋白长度
Partial
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分子量
18-20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin 11 (IL-11) is a member of the interleukin-6 (IL-6) family of cytokines and plays a crucial role in various physiological and pathological processes, including inflammation, tissue repair, and fibrosis. Initially identified for its role in promoting megakaryocyte development and platelet production, IL-11 has gained attention in recent years due to its involvement in pathological conditions such as chronic inflammatory diseases, cancer, and fibrotic disorders. The study of recombinant IL-11 proteins has become significant in understanding its biological functions and therapeutic potential. Research has shown that IL-11 can modulate immune responses, influencing T cell differentiation and activation. Moreover, its profibrotic properties make it a candidate for studying the mechanisms underlying organ fibrosis and developing targeted therapies. Recombinant IL-11 proteins are being investigated for their use in clinical settings, particularly for their potential to mitigate inflammation or promote tissue healing. The development of IL-11 as a therapeutic agent highlights the need for advanced recombinant protein production technologies to ensure safety, efficacy, and bioactivity. Overall, the research surrounding IL-11 recombinant proteins is essential for unraveling their complex roles in health and disease, paving the way for innovative treatment strategies that harness the unique properties of this cytokine.
