Analytical Data
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基因名
CD5
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简介
CD5 protein, a pivotal T-cell receptor, regulates T-cell proliferation through interactions with CD72/LYB-2. Its potential interaction with PTPN6/SHP-1 underscores its involvement in critical signaling pathways. CD5 Protein, Rat (HEK293, His) is the recombinant rat-derived CD5 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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生物活性
Immobilized Rat CD5 Protein at 1 μg/mL (100 μL/well) can bind Anti-CD5 Antibody, the ED50 for this effect is 18.65 ng/mL. Immobilized Rat CD5 Protein at 1 μg/mL (100 μL/well) can bind Anti-CD5 Antibody, the ED50 for this effect is 18.65 ng/mL.
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别名
T-cell surface glycoprotein CD5; Ly-1; Lyt-1; CD5; Leu-1
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种属
Rat
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51882
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表达区间
Q24-P368
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氨基酸序列
QSGRGFVGAQVMLSGSNSKCQGLVEVQMNGMKTVCSSSWRLSQDLWKNANEASTVCQQLGCGNPLALGHLTLWNRPKNQILCQGPPWSFSNCSTSSLGQCLPLSLVCLEPQKTTPLPTTTLPTTMPEPTAPPRLQLVPGHEGLRCTGVVEFYNGSRGGTILYKAKARPVDLGNLICKSLQCGSFLTHLSRIETAGTPAPAELRDPRPLPIRWEAQNGSCTSLQQCFQKTTVQEGSQALAVVCSDFQPKVQSRLVGGSSVCEGIAEVRQRSQWAALCDSSAARGPGRWEELCQEQQCGNLISFHVMDADRTSPGVLCTQEKLSQCYQLQKKTHCKRVFITCKDPNP
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蛋白长度
Partial
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分子量
50-56 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD5 is a type I transmembrane glycoprotein that plays a crucial role in modulating T cell and B cell functions within the immune system. It is primarily expressed on the surface of T lymphocytes and certain B cells, influencing their activation and survival. The study of CD5 has gained significant attention due to its contribution to immune responses and its potential implications in various diseases, particularly autoimmune disorders and cancers. Scientists have focused on the role of CD5 in enhancing T cell receptor (TCR) signaling and its interaction with other co-stimulatory molecules, which can alter immune cell behavior. Recombinant CD5 proteins have been developed for research purposes to investigate their biochemical properties and therapeutic potentials. These studies aim to uncover how CD5 modulation can be harnessed to improve immune responses in vaccine development or to develop novel treatments for cancers where CD5 is overexpressed or dysfunctional. As a result, understanding the structure and function of recombinant CD5 proteins may pave the way for innovative strategies in immunotherapy and the management of immune-related diseases.
