Cat: IPD-X30012

Recombinant Mouse CDKN1B Protein,His

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Analytical Data

  • 基因名

    CDKN1B

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CDKN4; KIP1; P27KIP1; p27; Cyclin-dependent kinase inhibitor p27

  • 种属

    Mouse

  • 表达系统

    E. coli

  • 标签

    N-His

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P46414

  • 表达区间

    Ser2~Thr197

  • 分子量

    26kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

CDKN1B, also known as p27Kip1, is a crucial cell cycle regulator that functions as an inhibitor of cyclin-dependent kinases (CDKs). Its primary role is to maintain the balance between cell proliferation and differentiation, making it a key player in tumor suppression. Abnormal expression or mutation of CDKN1B has been linked to various cancers, including breast, prostate, and colon cancer, highlighting its significance in oncogenesis. The study of recombinant CDKN1B protein has gained momentum as it can serve as a valuable tool for understanding its molecular mechanisms and interactions with other cell cycle proteins. By producing this protein in a recombinant form, researchers can establish in vitro assays to unravel the complexities of its regulatory functions and identify potential therapeutic targets. Furthermore, recombinant CDKN1B can be utilized in drug screening assays to discover new anticancer compounds that aim to restore its normal function or enhance its activity. Recent advances in recombinant DNA technology have facilitated the production of CDKN1B at scale, allowing for extensive functional studies and the exploration of its roles in cellular signaling pathways, apoptosis, and proliferation. Such research endeavors not only enhance our understanding of cancer biology but also pave the way for innovative treatment strategies that could combat tumor growth by modulating the activity of this pivotal cell cycle regulator.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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