Analytical Data
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基因名
CD158d/KIR2DL4
- Application
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别名
rHuCD158d, His; Killer Cell Immunoglobulin-Like Receptor 2DL4; CD158 Antigen-Like Family Member D; KIR-103AS; MHC Class I NK Cell Receptor KIR103AS; CD158d; KIR2DL4; KIR103AS
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
ADY38409.1
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表达区间
W22-H242
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氨基酸序列
WAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRTGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDASDPLPVSVTGNPSSSWPSPTEPSFKTGIARHLH
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蛋白长度
Partial
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分子量
30-40 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD158d, also known as KIR2DL4 (Killer Immunoglobulin-like Receptor 2DL4), is a prominent member of the killer immunoglobulin-like receptor (KIR) family, primarily expressed on natural killer (NK) cells and certain T cells. Its unique structure features a longer cytoplasmic tail that is believed to play a crucial role in immune regulation. KIR2DL4 is noteworthy for its ability to recognize the non-classical MHC class I molecule HLA-G, which is involved in immune tolerance, particularly during pregnancy and in tumor immunity. Research on the recombinant protein of KIR2DL4 has gained momentum due to its potential applications in immunotherapy and its ability to modulate immune responses. Understanding the interactions between KIR2DL4 and HLA-G can provide insights into the mechanisms of immune evasion by tumors and the maintenance of fetal-maternal tolerance. Recent studies focus on the characterization of the recombinant protein's binding affinity, signaling pathways, and functional assays to elucidate its role in NK cell activation and inhibition. This research could contribute to the development of novel therapeutic strategies that harness the immune system's capabilities to combat cancers and improve transplant outcomes by managing immune tolerance. Moreover, elucidating the role of KIR2DL4 in different disease contexts may pave the way for personalized medicine approaches, allowing for tailored interventions based on individual immune profiles. This emerging field of study underscores the importance of CD158d/KIR2DL4 as a significant player in the immune landscape, providing a promising avenue for therapeutic innovation.
